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The principal aim of this literature review is to identify a) the available health measurement scales for prediction of cardiovascular disease events in primary prevention and b) the results of the corresponding validation studies. With a focus on risk scales for primary prevention of cardiovascular disease events, this aim was achieved . . . Read more
To differentiate this Framingham scale from others, some papers have referred to it as the Framingham-D’Agostino scale (after the author) or the Cox-Framingham scale (as it was derived using the Cox proportional hazards model). 1) End-points measured 10-year risk of any cardiovascular disease (CVD) event. CVD is defined to include: . . . Read more
Background info: Framingham-ATP III ATP III is the recommended scale for the control and treatment of High Blood Cholesterol in Adults by the National Heart Lung and Blood Institute of US. ATP III constitute a revised Framingham scale derived from the Framingham-Wilson to measure hard CHD (total CHD without angina . . . Read more
Background info: Framingham-Anderson The Framingham-Anderson scale as originally presented by Anderson et al. has had many names associated with it in the literature, such as “Framingham risk score” or “Framingham heart study algorithm”. For ease of identifying and naming of the many scales developed by the Framingham Heart Study, we have chosen . . . Read more
Background info: Framingham-REGICOR Framingham-REGICOR is not a scale produced by the Framingham Heart Study investigators but an example of a relatively well-studied calibrated Framingham-ATPIII scale to the Spanish population. Framingham-ATPIII was chosen rather than Framingham-Wilson, at first, because the data from the REGICOR registry only contains information for “hard CHD” . . . Read more
Background info: Framingham-Wilson Framingham-Wilson is a scale generated to estimate risk of total CHD in contradistinction to hard CHD (total CHD without angina pectoris) . The Framingham Heart Study used ECG to measure silent MI or angina. However, the application of ECG is often absent in other validation cohort studies, limiting . . . Read more
The following studies did not specify clearly which version of Framingham scale was used and hence cannot be categorised. References 1. Ferrario M, Chiodini P, Chambless LE, et al. Prediction of coronary events in a low incidence population. Assessing accuracy of the CUORE Cohort Study prediction equation. International Journal of . . . Read more
Background info: RICORNA RICORNA is an adaption of the Framingham-Wilson equation for Navarra, Spain. 1) End-points measured 10 year risk of total coronary heart disease (CHD) Total CHD is defined to include: Angina pectoris Myocardial infarction Coronary death 2) Profile of original population at baseline Navarra, Spain Age: 35 to . . . Read more
Timeline for Framingham risk scales Before reviewing the available validation studies for Framingham risk scales, it is important to have a basic understanding of the timeline for these scales. This is because each Framingham scale is designed to measure a different and specific CVD outcome or is generated using different . . . Read more
Timeline for Framingham risk scales Framingham General Cardiovascular Risk Profile Framingham – Wilson Framingham – Anderson Examples of scales derived from the Framingham Heart Study: Framingham – REGICOR Framingham – ATP (Adult Treatment Panel) III RICORNA